goranDr Göran Skog, NIMI (Norwegian Institute for Sports Medicine)
I first began using Crespine Gel when I started at NIMI in November 2010. I do a lot of injections with the use of x-ray, including hips. In a short period of time, I treated about 20 hips with Crespine Gel and I am impressed by the immediate effect it has
on the patients I have treated. Most of them have experienced significant improvement immediately! I look forward with excitement to the long-term follow-up of these patients.

rafnDr. Rafn Lindal Björnsson, NIMI (Norwegian Institute for Sports Medicine)
Throughout 2010 I treated many patients with Crespine Gel, giving injections in ankles, knees, hips and shoulders. I find it to be a very exciting product. Crespine Gel seems to have a longerlasting effect than other types of hyaluronic acid products and cortisone. This means less-frequent injections for the patient and less expense.

wolfgangDr Wolfgang Schmitt, OTS Clinic, Marbella
As a consulting orthopedic surgeon, I have used Crespine Gel for one year on over 100 selected patients. There have been no complications in tolerance of the implant ( gel ) . Most of my patients have osteoarthritis of the knee joint. Even for grade III osteoarthritis, Crespine Gel can be used to delay knee replacement. Good indications for use of Crespine Gel are also rotator cuff tears ( old ) or older patients with secondary osteoarthritis of the shoulder joint. Even the single shot application is something very convenient for the patient because they only have to come for treatment once, get only one injection with one risk of joint infection. In serious arthritis cases we had to repeat the injection after 4 months, but the average effectiveness was 6 to 12 months.



Osteoarthritis is caused by the breakdown of cartilage. Cartilage is the tough elastic material that covers and protects the ends of bones. Bits of cartilage may break off and cause pain and swelling in the joint between bones. This pain and swelling is called inflammation. Over time the cartilage may wear away entirely, and the bones will rub together. Osteoarthritis can affect any joint but usually affects hips, knees, hands and spine.
Osteoarthritis is a disease that affects joints in the body. It can involve any joint, but usually concerns hands and weight-bearing joints such as hips, knees, feet and spine.

Cartilage is the tough elastic material that covers and protects the ends of bones. In healthy joints cartilage acts as a shock absorber when you put weight on the joint. The slippery surface of the cartilage allows the bones to move smoothly. When a joint develops osteoarthritis the cartilage gradually becomes rough and thin, and the bone underneath thickens.

Osteoarthritis is classified as non-inflammatory arthritis. This suggests that there is no inflammation (swelling), but recent research shows that this is not true. Although there is usually no swelling in the early stage of the disease, as the arthritis progresses there can be inflammation. Bits of cartilage may break off and float around inside the joint. This disturbs other soft tissues inside the joint and can cause pain and swelling between bones. The result is you may have trouble moving the joint.

Over time as the cartilage wears down, the bones may form bumps on their ends. These bumps are called spurs. Or, the cartilage may wear away entirely, and your bones may rub together.

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